History of periodontal disease diagnosis and lung cancer incidence in the Women’s Health Initiative Observational Study
Identifieur interne : 001A32 ( Main/Exploration ); précédent : 001A31; suivant : 001A33History of periodontal disease diagnosis and lung cancer incidence in the Women’s Health Initiative Observational Study
Auteurs : Xiaodan Mai ; Michael J. Lamonte ; Kathleen M. Hovey ; Ngozi Nwizu ; Jo L. Freudenheim ; Mine Tezal ; Frank Scannapieco ; Andrew Hyland ; Christopher A. Andrews ; Robert J. Genco ; Jean Wactawski-WendeSource :
- Cancer causes & control : CCC [ 0957-5243 ] ; 2014.
Abstract
While some evidence suggests that periodontal disease (PD) might be positively associated with lung cancer, prospective studies in women are limited. Previous findings may reflect residual confounding by smoking. The study aims to determine whether history of PD diagnosis is associated with incident lung cancer in a large cohort of postmenopausal women.
Prospective analyses were conducted in a cohort of 77,485 postmenopausal women enrolled in the Women’s Health Initiative Observational Study. History of PD (prevalence of 26.1%) was self-reported and 754 incident lung cancer cases occurred during an average 6.8 (SD ±2.6) years of follow-up. Cox regression analysis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
Overall, PD was positively associated with lung cancer risk after adjusting for detailed smoking history including smoking status and pack-years of smoking (HR=1.24, 95% CI: 1.07–1.45). There was a positive additive interaction between PD with pack-years of smoking (P=0.02), suggesting a potential synergistic effect between PD and smoking intensity on lung cancer. The association between PD and lung cancer was stronger in former smokers. When restricted to never-smokers, PD was not associated with lung cancer (HR=1.02, 95% CI: 0.68–1.53).
PD was not independently associated with lung cancer in non-smoking postmenopausal women. However, smoking and PD jointly increased lung cancer risk beyond that expected from the sum of the each effect separately. The potential synergism between PD and smoking on lung cancer warrants further examination.
Url:
DOI: 10.1007/s10552-014-0405-3
PubMed: 24913780
PubMed Central: 4117379
Affiliations:
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Women’s Health Initiative Observational Study</title><author><name sortKey="Mai, Xiaodan" sort="Mai, Xiaodan" uniqKey="Mai X" first="Xiaodan" last="Mai">Xiaodan Mai</name></author><author><name sortKey="Lamonte, Michael J" sort="Lamonte, Michael J" uniqKey="Lamonte M" first="Michael J." last="Lamonte">Michael J. Lamonte</name></author><author><name sortKey="Hovey, Kathleen M" sort="Hovey, Kathleen M" uniqKey="Hovey K" first="Kathleen M." last="Hovey">Kathleen M. Hovey</name></author><author><name sortKey="Nwizu, Ngozi" sort="Nwizu, Ngozi" uniqKey="Nwizu N" first="Ngozi" last="Nwizu">Ngozi Nwizu</name></author><author><name sortKey="Freudenheim, Jo L" sort="Freudenheim, Jo L" uniqKey="Freudenheim J" first="Jo L." last="Freudenheim">Jo L. Freudenheim</name></author><author><name sortKey="Tezal, Mine" sort="Tezal, Mine" uniqKey="Tezal M" first="Mine" last="Tezal">Mine Tezal</name></author><author><name sortKey="Scannapieco, Frank" sort="Scannapieco, Frank" uniqKey="Scannapieco F" first="Frank" last="Scannapieco">Frank Scannapieco</name></author><author><name sortKey="Hyland, Andrew" sort="Hyland, Andrew" uniqKey="Hyland A" first="Andrew" last="Hyland">Andrew Hyland</name></author><author><name sortKey="Andrews, Christopher A" sort="Andrews, Christopher A" uniqKey="Andrews C" first="Christopher A." last="Andrews">Christopher A. Andrews</name></author><author><name sortKey="Genco, Robert J" sort="Genco, Robert J" uniqKey="Genco R" first="Robert J." last="Genco">Robert J. Genco</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24913780</idno><idno type="pmc">4117379</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117379</idno><idno type="RBID">PMC:4117379</idno><idno type="doi">10.1007/s10552-014-0405-3</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002756</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002756</idno><idno type="wicri:Area/Pmc/Curation">002756</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002756</idno><idno type="wicri:Area/Pmc/Checkpoint">001437</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001437</idno><idno type="wicri:Area/Ncbi/Merge">005170</idno><idno type="wicri:Area/Ncbi/Curation">005170</idno><idno type="wicri:Area/Ncbi/Checkpoint">005170</idno><idno type="wicri:doubleKey">0957-5243:2014:Mai X:history:of:periodontal</idno><idno type="wicri:Area/Main/Merge">001A38</idno><idno type="wicri:Area/Main/Curation">001A32</idno><idno type="wicri:Area/Main/Exploration">001A32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">History of periodontal disease diagnosis and lung cancer incidence in the
Women’s Health Initiative Observational Study</title><author><name sortKey="Mai, Xiaodan" sort="Mai, Xiaodan" uniqKey="Mai X" first="Xiaodan" last="Mai">Xiaodan Mai</name></author><author><name sortKey="Lamonte, Michael J" sort="Lamonte, Michael J" uniqKey="Lamonte M" first="Michael J." last="Lamonte">Michael J. Lamonte</name></author><author><name sortKey="Hovey, Kathleen M" sort="Hovey, Kathleen M" uniqKey="Hovey K" first="Kathleen M." last="Hovey">Kathleen M. Hovey</name></author><author><name sortKey="Nwizu, Ngozi" sort="Nwizu, Ngozi" uniqKey="Nwizu N" first="Ngozi" last="Nwizu">Ngozi Nwizu</name></author><author><name sortKey="Freudenheim, Jo L" sort="Freudenheim, Jo L" uniqKey="Freudenheim J" first="Jo L." last="Freudenheim">Jo L. Freudenheim</name></author><author><name sortKey="Tezal, Mine" sort="Tezal, Mine" uniqKey="Tezal M" first="Mine" last="Tezal">Mine Tezal</name></author><author><name sortKey="Scannapieco, Frank" sort="Scannapieco, Frank" uniqKey="Scannapieco F" first="Frank" last="Scannapieco">Frank Scannapieco</name></author><author><name sortKey="Hyland, Andrew" sort="Hyland, Andrew" uniqKey="Hyland A" first="Andrew" last="Hyland">Andrew Hyland</name></author><author><name sortKey="Andrews, Christopher A" sort="Andrews, Christopher A" uniqKey="Andrews C" first="Christopher A." last="Andrews">Christopher A. Andrews</name></author><author><name sortKey="Genco, Robert J" sort="Genco, Robert J" uniqKey="Genco R" first="Robert J." last="Genco">Robert J. Genco</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author></analytic><series><title level="j">Cancer causes & control : CCC</title><idno type="ISSN">0957-5243</idno><idno type="eISSN">1573-7225</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">While some evidence suggests that periodontal disease (PD) might be positively
associated with lung cancer, prospective studies in women are limited. Previous findings
may reflect residual confounding by smoking. The study aims to determine whether history
of PD diagnosis is associated with incident lung cancer in a large cohort of
postmenopausal women.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Prospective analyses were conducted in a cohort of 77,485 postmenopausal women
enrolled in the Women’s Health Initiative Observational Study. History of PD
(prevalence of 26.1%) was self-reported and 754 incident lung cancer cases
occurred during an average 6.8 (SD ±2.6) years of follow-up. Cox regression
analysis was used to estimate hazard ratios (HRs) and 95% confidence intervals
(CIs).</p></sec><sec id="S3"><title>Results</title><p id="P3">Overall, PD was positively associated with lung cancer risk after adjusting for
detailed smoking history including smoking status and pack-years of smoking (HR=1.24,
95% CI: 1.07–1.45). There was a positive additive interaction between PD
with pack-years of smoking (P=0.02), suggesting a potential synergistic effect between
PD and smoking intensity on lung cancer. The association between PD and lung cancer was
stronger in former smokers. When restricted to never-smokers, PD was not associated with
lung cancer (HR=1.02, 95% CI: 0.68–1.53).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">PD was not independently associated with lung cancer in non-smoking
postmenopausal women. However, smoking and PD jointly increased lung cancer risk beyond
that expected from the sum of the each effect separately. The potential synergism
between PD and smoking on lung cancer warrants further examination.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Andrews, Christopher A" sort="Andrews, Christopher A" uniqKey="Andrews C" first="Christopher A." last="Andrews">Christopher A. Andrews</name><name sortKey="Freudenheim, Jo L" sort="Freudenheim, Jo L" uniqKey="Freudenheim J" first="Jo L." last="Freudenheim">Jo L. Freudenheim</name><name sortKey="Genco, Robert J" sort="Genco, Robert J" uniqKey="Genco R" first="Robert J." last="Genco">Robert J. Genco</name><name sortKey="Hovey, Kathleen M" sort="Hovey, Kathleen M" uniqKey="Hovey K" first="Kathleen M." last="Hovey">Kathleen M. Hovey</name><name sortKey="Hyland, Andrew" sort="Hyland, Andrew" uniqKey="Hyland A" first="Andrew" last="Hyland">Andrew Hyland</name><name sortKey="Lamonte, Michael J" sort="Lamonte, Michael J" uniqKey="Lamonte M" first="Michael J." last="Lamonte">Michael J. Lamonte</name><name sortKey="Mai, Xiaodan" sort="Mai, Xiaodan" uniqKey="Mai X" first="Xiaodan" last="Mai">Xiaodan Mai</name><name sortKey="Nwizu, Ngozi" sort="Nwizu, Ngozi" uniqKey="Nwizu N" first="Ngozi" last="Nwizu">Ngozi Nwizu</name><name sortKey="Scannapieco, Frank" sort="Scannapieco, Frank" uniqKey="Scannapieco F" first="Frank" last="Scannapieco">Frank Scannapieco</name><name sortKey="Tezal, Mine" sort="Tezal, Mine" uniqKey="Tezal M" first="Mine" last="Tezal">Mine Tezal</name><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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